Branched-chain Amino Acid Catabolism by Brown Adipose Tissue
نویسندگان
چکیده
منابع مشابه
Regulation of branched-chain amino acid catabolism.
Catabolism of the branched-chain amino acids is regulated in part at the step catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex. Previous work suggests both short-term and long-term control mechanisms are involved in regulation of the kinase responsible for phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex. Recent work of this laborat...
متن کاملBranched-chain amino acid catabolism in bacteria.
The enzymatic conversions necessary for the catabolism of branched-chain amino acids have been reported to occur in a wide variety of bacteria. However, most studies have been done using several species of Pseudomonas. Pseudomonads are richly endowed with extraordinary nutritional versatility, which enables them to catabolize a diverse array of organic compounds (64), including the branchedchai...
متن کاملRegulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.
Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or incomplete BCAA oxidation. White adipose tissue (WAT) has become appreciated as a potential player in whole body BCAA metabolism. We tested if expression of the mitochondrial BCAA oxidation checkpoint, branched-chain α-k...
متن کاملDoctorial Thesis Regulation of Branched-Chain Amino Acid Catabolism
........................................................................................................... 1 Abbreviations ................................................................................................... 3 Chapter 1 General introduction ........................................................................ 3 1. The importance of branched chain amino acids ....................
متن کاملBranched chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Adipose tissue plays important roles in regulating carbohydrate and lipid homeostasis, but less is known about the regulation of amino acid metabolism in adipocytes. Here we applied isotope tracing to pre-adipocytes and differentiated adipocytes to quantify the contributions of different substrates to tricarboxylic acid (TCA) metabolism and lipogenesis. In contrast to proliferating cells, which...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinology
سال: 2020
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endocr/bqaa060